古庆悦;李鑫森;徐嘉伟;唐玉玲;孟迪;胡艳欣;

• 1:中国农业大学动物医学院

摘要(Abstract)：

<正>褪黑素(Melatonin)是一种胺类激素，由色氨酸合成，除松果体和视网膜外，在体内组织器官，如骨髓、肝脏、胃肠道、皮肤、卵巢、睾丸、胎盘等中均可合成褪黑素。近年来大量研究发现，褪黑素不仅具有昼夜节律调节作用，还具有良好的免疫调节作用，在抗感染、抗肿瘤，以及治疗眼部疾病、胃肠道疾病、类风湿性关节炎等疾病中具有潜在的临床应用价值。本文将从褪黑素的抗病毒作用及其机制进行综述，以期为褪黑素在临床抗病毒领域的应用提供借鉴。

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 古庆悦;李鑫森;徐嘉伟;唐玉玲;孟迪;胡艳欣;

参考文献(References)：

• [1] Venegas C,García J A,Escames G,et al.Extrapineal melatonin:analysis of its subcellular distribution and daily fluctuations[J].Journal of Pineal Research,2012,52(2):217- 227.
• [2] Zhai X,Wang N,Jiao H,et al.Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations[J].Journal of Pineal Research,2021,71(2):e12754.
• [3] San-Miguel B,Crespo I,Vallejo D,et al.Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus[J].Journal of Pineal Research,2014,56(3):313- 321.
• [4] Tuňón M J,Miguel B S,Crespo I,et al.Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus[J].Journal of Pineal Research,2011,50(1):38- 45.
• [5] Laliena A,Miguel B S,Crespo I,et al.Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin[J].Journal of Pineal Research,2012,53(3):270- 278.
• [6] Wang Y,Yang G,Zhang L,et al.Melatonin as immune potentiator for enhancing subunit vaccine efficacy against bovine viral diarrhea virus[J].Vaccines,2021,9(9):1039.
• [7] Ellis L C.Melatonin reduces mortality from Aleutian disease in mink (Mustela vison)[J].Journal of Pineal Research,1996,21(4):214- 217.
• [8] Zhou Y,Hou Y,Shen J,et al.Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2[J].Cell Discovery,2020,6(1):14.
• [9] Jehi L,Ji X,Milinovich A,et al.Individualizing risk prediction for positive coronavirus disease 2019 testing[J].Chest,2020,158(4):1364- 1375.
• [10] Bonilla E,Valero-Fuenmayor N,Pons H,et al.Melatonin protects mice infected with Venezuelan equine encephalomyelitis virus[J].Cellular and Molecular Life Sciences,1997,53(5):430- 434.
• [11] Montiel M,Bonilla E,Valero N,et al.Melatonin decreases brain apoptosis,oxidative stress,and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus[J].Antiviral Chemistry and Chemotherapy,2015,24(3- 4):99- 108.
• [12] Huang S,Liao C,Chen S,et al.Melatonin possesses an anti-influenza potential through its immune modulatory effect[J].Journal of Functional Foods,2019,58:189- 198.
• [13] Vidya Vijayan K K,Karthigeyan K P,Tripathi S P,et al.Pathophysiology of CD4+ T-cell depletion in HIV-1 and HIV-2 infections[J].Frontiers in Immunology,2017,8:580.
• [14] Nunnari G,Nigro L,Palermo F,et al.Reduction of serum melatonin levels in HIV-1-infected individuals' parallel disease progression:correlation with serum interleukin-12 levels[J].Infection,2003,31(6):379- 382.
• [15] Lissoni P,Vigore L,Rescaldani R,et al.Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3:a biological phase-II study[J].J Biol Regul Homeost Agents,1995,9(4):155- 158.
• [16] Huang S,Cao X,Liu W,et al.Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice[J].Journal of Pineal Research,2010,48(2):109- 116.
• [17] Edgar R S,Stangherlin A,Nagy A D,et al.Cell autonomous regulation of herpes and influenza virus infection by the circadian clock[J].Proceedings of the National Academy of Sciences,2016,113(36):10085- 10090.
• [18] Nunes O D S,Pereira R D S.Regression of herpes viral infection symptoms using melatonin and SB-73:comparison with Acyclovir[J].Journal of Pineal Research,2008,44(4):373- 378.
• [19] Morchang A,Malakar S,Poonudom K,et al.Melatonin inhibits dengue virus infection via the sirtuin 1-mediated interferon pathway[J].Viruses,2021,13(4):659.
• [20] Haldar C,Rai S,Singh R.Melatonin blocks dexamethasone-induced immunosuppression in a seasonally breeding rodent Indian palm squirrel,Funambulus pennanti[J].Steroids,2004,69(6):367- 377.
• [21] Rodriguez A B,Terron M P,Duran J,et al.Physiological concentrations of melatonin and corticosterone affect phagocytosis and oxidative metabolism of ring dove heterophils[J].J Pineal Res,2001,31(1):31- 38.
• [22] Valero N,MarinaEspina L,Bonilla E,et al.Melatonin decreases nitric oxide production and lipid peroxidation and increases interleukin-1 beta in the brain of mice infected by the Venezuelan equine encephalomyelitis virus[J].Journal of Pineal Research,2007,42(2):107- 112.
• [23] Zhang Y,Li X,Grailer J J,et al.Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome[J].Journal of Pineal Research,2016,60(4):405- 414.
• [24] Cotrim A C D M,Fran?a E L,Martins J S,et al.Correlation between melatonin concentration and cytokines in cervical mucus in positive samples for the presence of human papillomavirus[J].Cancer Immunology,Immunotherapy,2021,70(9):2721- 2726.
• [25] Ucar M,Korkmaz A,Reiter R J,et al.Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard[J].Toxicology Letters,2007,173(2):124- 131.
• [26] NaveenKumar S K,Hemshekhar M,Jagadish S,et al.Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system[J].Journal of Pineal Research,2020,69(3):e12676.
• [27] Ouyang H,Zhong J,Lu J,et al.Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunction[J].Journal of Molecular Histology,2019,50(5):405- 415.
• [28] Jeong J,Moon M,Lee Y,et al.Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity[J].Journal of Pineal Research,2012,53(2):138- 146.
• [29] Vlachou M,Siamidi A,Dedeloudi A,et al.Pineal hormone melatonin as an adjuvant treatment for COVID19 (review)[J].Int J Mol Med,2021,47(4):47.
• [30] Andersen L P H,G?genur I,Rosenberg J,et al.The safety of melatonin in humans[J].Clinical Drug Investigation,2016,36(3):169- 175.